176 ON THE IL
 TOR | Addison Barger | RF | Injured 60-Day | 07/23 | Right elbow inflammation |
| TOR | Anthony Santander | RF | Injured 60-Day | 04/05 | Left shoulder labral tear |
| TOR | Bowden Francis | P | Injured 60-Day | 02/18 | Right elbow surgery |
| TOR | Cody Ponce | P | Injured 60-Day | 04/05 | Right knee ACL sprain |
| TOR | Jake Bloss | P | Injured 60-Day | 08/12 | NOT DISCLOSED |
| TOR | Jonatan Clase | LF | Injured 60-Day | 08/27 | Left plantar fasciitis |
| TOR | José Berríos | P | Injured 60-Day | 05/27 | Right elbow stress fracture |
| TOR | Patrick Corbin | P | Injured 60-Day | 08/05 | Left teres major strain |
| TOR | Yimi García | P | Injured 60-Day | 04/25 | Right elbow ulnar nerve and AC joint surgery |
 BAL | Colin Selby | P | Injured 60-Day | 02/14 | Right shoulder inflammation |
| BAL | Jordan Westburg | 3B | Injured 60-Day | 04/01 | Right elbow UCL sprain |
| BAL | Keegan Akin | P | Injured 60-Day | 07/13 | Left elbow discomfort |
| BAL | Kyle Bradish | P | Injured 60-Day | 09/24 | Lower abdominal discomfort |
| BAL | Ryan Helsley | P | Injured 60-Day | 07/19 | Right elbow discomfort |
| BAL | Ryan Mountcastle | 1B | Injured 60-Day | 04/13 | Left foot fracture |
| BAL | Tyler O'Neill | RF | Injured 60-Day | 09/19 | Right shoulder inflammation |
| BAL | Zach Eflin | P | Injured 60-Day | 04/07 | Right elbow discomfort |
 TB | Edwin Uceta | P | Injured 60-Day | 04/24 | Right shoulder impingement |
| TB | Gavin Lux | LF | Injured 60-Day | 05/27 | Right shoulder impingement |
| TB | Jacob Melton | LF | Injured 60-Day | 09/15 | Right hamstring strain |
| TB | Jonathan Heasley | P | Injured 60-Day | 06/08 | NOT DISCLOSED |
| TB | Ryan Pepiot | P | Injured 60-Day | 04/14 | Right hip inflammation |
 BOS | Eduardo Rivera | P | Injured 60-Day | 09/01 | Lumbar strain |
| BOS | Eli White | CF | Injured 60-Day | 09/27 | Right foot ligament injury |
| BOS | Johan Oviedo | P | Injured 60-Day | 04/14 | Right elbow strain |
| BOS | Justin Slaten | P | Injured 60-Day | 09/29 | Right elbow inflammation |
| BOS | Kutter Crawford | P | Injured 60-Day | 05/22 | Right wrist surgery |
| BOS | Triston Casas | 1B | Injured 60-Day | 04/22 | Recovery from left patellar tendon repair |
| BOS | Zack Kelly | P | Injured 60-Day | 07/21 | Right elbow inflammation |
 NYY | Clarke Schmidt | P | Injured 15-Day | 09/24 | Right bicep neuritis |
| NYY | Fernando Cruz | P | Injured 60-Day | 09/25 | Right elbow discomfort |
| NYY | Kervin Castro | P | Injured 60-Day | 08/26 | Right elbow neuritis |
 KC | Alec Marsh | P | Injured 60-Day | 02/12 | Right shoulder impingement |
| KC | Carlos Estévez | P | Injured 60-Day | 06/15 | Left foot contusion |
| KC | Cole Ragans | P | Injured 60-Day | 06/17 | Left elbow impingement |
| KC | Connor Seabold | P | Injured 60-Day | 08/03 | Right lat strain |
| KC | Jonathan India | 2B | Injured 60-Day | 06/04 | Left shoulder subluxation |
| KC | Luinder Avila | P | Injured 60-Day | 08/06 | Right forearm tightness |
| KC | Nick Mears | P | Injured 60-Day | 07/14 | Right shoulder impingement |
| KC | Stephen Kolek | P | Injured 60-Day | 07/22 | Right flexor strain |
 DET | Bailey Horn | P | Injured 60-Day | 04/22 | Left elbow arthroscopy recovery |
| DET | Burch Smith | P | Injured 60-Day | 06/23 | Right shoulder inflammation |
| DET | Kerry Carpenter | RF | Injured 60-Day | 09/26 | Left foot plantar fasciitis |
| DET | Matt Vierling | CF | Injured 60-Day | 09/06 | Left adductor strain |
| DET | Parker Meadows | CF | Injured 60-Day | 04/13 | Left radius fracture |
| DET | Reese Olson | P | Injured 60-Day | 02/10 | Right Shoulder Labral Repair |
| DET | Trey Sweeney | SS | Injured 60-Day | 04/11 | Right shoulder strain |
| DET | Wenceel Pérez | RF | Injured 60-Day | 06/26 | Left orbital fracture |
| DET | Will Vest | P | Injured 60-Day | 07/19 | Right posterior elbow inflammation |
 MIN | Anthony Banda | P | Injured 60-Day | 07/11 | Left lat strain |